Information for Health Professionals

Research Tests List

1. Cytochrome P450 genotyping

Depending on ethnicity, between 10-15% of the population are poor metabolisers. That is, they do not have the enzymes necessary to clear specific drugs from their body, and therefore have an increased risk of adverse drug reaction. These three tests cover up to 60% of commonly prescribed medication.  

2. Protein p53  

The p53 protein acts to induce cell cycle arrest or apoptosis in response to DNA damage, thereby maintaining genetic stability in the organism and acting as a tumor suppressor.  

3. DNA Damage (ARP - apurinic/apyrimidinic sites) 

The level of AP sites in a cell is an indicator of DNA lesions and repair against chemical damage and cell aging.  

4. PPAR2 Pro12Ala genotyping 

This polymorphism in the PPAR2 gene may decrease the risk for insulin resistance, type 2 diabetes and heart disease.  

5. DNA methylation (MSP) 

DNA methylation is a type of chemical modification that can be inherited and subsequently removed without changing the original DNA sequence. DNA methylation is essential for normal development and is associated with a number of key processes including imprinting, X-chromosome inactivation, suppression of genes and carcinogenesis.

6. TPMT genotyping 

Active thiopurine drug derivatives can accumulate in patients who have reduced TPMT activity and who are receiving standard thiopurine doses. This can lead to severe and possibly fatal myelosuppression.

7. HLAB*1502 genotyping 

This genotype is found in certain ethnic populations and can result in serious dermatological reactions to carbamazepine.
 

8. VKORC1 genotyping 

Polymorphism in this gene contributes to the variability in the warfarin dose requirements.
 

Please note:

These tests are available to interested medical practitioners for research purposes. Set up of other tests can be negotiated. For further information please contact the laboratory.